Luxury escapes

Luxury Hotels in Muscatine

We've selected 17 of the Best Luxury hotels in Muscatine for your 2026 vacation!

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Top luxury hotels in Muscatine

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9
Excellent
51 Reviews

From

134$/night

The Merrill Hotel & Conference Center, Muscatine, A Tribute Portfolio Hotel

119 West Mississippi Drive
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9
Excellent
307 Reviews

From

109$/night

Hyatt Regency Coralville

300 East 9Th Street
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8.8
Excellent
129 Reviews

From

102$/night

Holiday Inn Express Bettendorf - Davenport Ne By Ihg

5061 Competition Drive
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Boutique luxury hotels in Muscatine

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8.2
Very good
477 Reviews

From

80$/night

Comfort Inn & Suites Davenport - Quad Cities

8300 Northwest Boulvard
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8.6
Excellent
111 Reviews

From

95$/night

Sleep Inn & Suites Mount Vernon

310 Virgil Avenue
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9
Excellent
94 Reviews

From

122$/night

Hotel Chauncey Iowa City, Tapestry Collection By Hilton

404 E College St
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8.9
Excellent
54 Reviews

From

155$/night

The Axis Moline Hotel, Tapestry Collection By Hilton

1630 5Th Avenue
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7.9
Very good
262 Reviews

From

130$/night

Comfort Suites Burlington

1780 Stonegate Center Drive
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9.4
Excellent
11 Reviews

From

112$/night

The Hotel At Kirkwood Center

7725 Kirkwood Blvd Sw
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8.3
Very good
120 Reviews

From

168$/night

Comfort Inn & Suites Riverview Near Davenport And I-80

902 Mississippi View Court
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7.2
Good
297 Reviews

From

102$/night

Doubletree By Hilton Davenport

111 E Second Street
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7.3
Good
99 Reviews

From

99$/night

Quality Inn & Suites Mount Pleasant

1200 East Baker Street
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7.4
Good
99 Reviews

From

117$/night

Mainstay Suites Leclaire - Quad Cities

1552 Welcome Center Drive Building A
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7.8
Very good
86 Reviews

From

168$/night

Hotel Blackhawk, Autograph Collection

200 East 3Rd Street
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6.6
Good
80 Reviews

From

69$/night

Quality Inn & Suites Eldridge Davenport North

1000 East Iowa Street
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8
Very good
29 Reviews

From

139$/night

The Current Iowa, Autograph Collection

215 North Main Street
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7.6
Very good
226 Reviews

From

86$/night

Sleep Inn & Suites North Liberty - Liberty City

485 Madison Ave. North
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Location

Muscatine, Iowa, United States, 52761

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